反应详情

To a suspension of N-(2-aminoethyl)-5-(5-fluoropentyl)-1-(4-{[(2,2,2-trifluoroethyl)amino]carbonyl}phenyl)-1H-1,2,3-triazole-4-carboxamide monohydrochloride (0.12 g) obtained in Example 296 in dichloromethane (5.0 ml) were added triethylamine (0.07 ml) and 1-fluoro-3-isocyanatobenzene (0.06 ml), and the mixture was stirred at room temperature overnight. Water was added to the reaction mixture, and the resultant precipitate was collected by filtration, washed with water and recrystallized from ethanol-water to give the title compound as a white powder (0.14 g, 98%).

1. filtrationthe resultant precipitate was collected by filtration
2. washwashed with water
3. customrecrystallized from ethanol-water