HCID 23130247, compound → HCID 43380150, compound

HRID 1717366Notes

Reaction equation

HRID 1717366 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[N+:14]([O-])=O)[C:7]([O:9][CH3:10])=[O:8])[CH3:2]>CO.C1COCC1.[Pd]>[NH2:14][C:13]1[CH:12]=[CH:11][C:6]([C:7]([O:9][CH3:10])=[O:8])=[CH:5][C:4]=1[O:3][CH2:1][CH3:2]

Participants

5

Reactant 1

HCID 23130247HCID 23130247, compound

Product 1

HCID 43380150HCID 43380150, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

To a mixed solution of methyl 3-ethoxy-4-nitrobenzoate (6.05 g) in methanol (100 ml) and THF (100 ml) was added 10% Pd/C (50% wet, 0.60 g), and the mixture was stirred under a hydrogen atmosphere overnight. The reaction mixture was filtered through celite, and the filtrate was evaporated under reduced pressure to give a crude product (5.21 g) of the title compound. The obtained crude product was used for the next reaction without further purification.

Workup

  1. filtrationThe reaction mixture was filtered through celite
  2. customthe filtrate was evaporated under reduced pressure
  3. customto give a crude product (5.21 g) of the title compound
  4. customThe obtained crude product
  5. customwas used for the next reaction without further purification

Sources & evidence

ORD record
ord-013b9ee542ec4ba0a684576dacf9e36c
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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