N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-[(E)-2-(1,3-thiazol-2-yl)vinyl]-1H-1,2,3-triazole-4-carboxamide → N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-[2-(1,3-thiazol-2-yl)ethyl]-1H-1,2,3-triazole-4-carboxamide

HRID 1717377Notes

Reaction equation

HRID 1717377 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:19]3[CH:24]=[CH:23][C:22]([C:25]([NH:27][CH2:28][CH3:29])=[O:26])=[CH:21][CH:20]=3)[C:11]=2/[CH:12]=[CH:13]/[C:14]2[S:15][CH:16]=[CH:17][N:18]=2)=[O:6])[CH2:3][CH2:2]1>CN(C=O)C.[Pd]>[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:19]3[CH:20]=[CH:21][C:22]([C:25]([NH:27][CH2:28][CH3:29])=[O:26])=[CH:23][CH:24]=3)[C:11]=2[CH2:12][CH2:13][C:14]2[S:15][CH:16]=[CH:17][N:18]=2)=[O:6])[CH2:2][CH2:3]1

Participants

4

Reactant 1

HCID 57664936N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-[(E)-2-(1,3-thiazol-2-yl)vinyl]-1H-1,2,3-triazole-4-carboxamide

Product 1

HCID 57665049N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-[2-(1,3-thiazol-2-yl)ethyl]-1H-1,2,3-triazole-4-carboxamideYield 76.5%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 6228DimethylformamideSolvent

Procedure

To a solution of N-cyclopropyl-1-{4-[(ethylamino)carbonyl]phenyl}-5-[(E)-2-(1,3-thiazol-2-yl)vinyl]-1H-1,2,3-triazole-4-carboxamide (130 mg) obtained in Example 321 in DMF (10 ml) was added 10% Pd/C (50% wet, 15 mg), and the mixture was stirred for 3 days under a hydrogen atmosphere. After the reaction mixture was filtered through celite, the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column (ethyl acetate to ethyl acetate/methanol=4/1) to give the title compound as a white powder (100 mg).

Workup

  1. filtrationAfter the reaction mixture was filtered through celite
  2. customthe filtrate was evaporated under reduced pressure
  3. customThe residue was purified by silica gel column (ethyl acetate to ethyl acetate/methanol=4/1)

Sources & evidence

ORD record
ord-3ba2a3d7f1fe4795b78cd2f1afa66b1e
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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