Thionyl Chloride → HCID 18450777, compound

HRID 17174Notes

Reaction equation

HRID 17174 reaction equation
[NH2:1][C:2]1[C:7]2[C:8]([Br:11])=[CH:9][S:10][C:6]=2[C:5]([C:12]2[CH:13]=[C:14]([CH2:18]O)[CH:15]=[CH:16][CH:17]=2)=[CH:4][N:3]=1.O=S(Cl)[Cl:22]>C(Cl)(Cl)Cl>[Br:11][C:8]1[C:7]2[C:2]([NH2:1])=[N:3][CH:4]=[C:5]([C:12]3[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][Cl:22])[CH:13]=3)[C:6]=2[S:10][CH:9]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 18450706[3-(4-Amino-3-bromothieno[3,2-c]pyridin-7-yl)phenyl]methanol

Product 1

HCID 18450777HCID 18450777, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of example 673A (550 mg, 1.64 mmol) in CHCl3 (5 mL) was treated with SOCl2 (5 mL), stirred at room temperature for 3 hours then concentrated to give the title compound. MS (ESI(+)) m/e 352.7, 354.7 (M+H)+.

Workup

  1. concentrationthen concentrated

Sources & evidence

ORD record
ord-6e4c0e72dc3a4419b9f32d7240cafe40
Source dataset
uspto-grants-2010_06
Patent number
US07737160B2

Reaction notes

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