Hydrazine hydrate (1:1) → HCID 57665091, compound

HRID 1717412Notes

Reaction equation

HRID 1717412 reaction equation
[CH:1]1([NH:4][C:5]([C:7]2[N:8]=[N:9][N:10]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([NH:34][CH2:35][CH3:36])=[O:33])=[CH:28][CH:27]=3)[C:11]=2[CH2:12][CH2:13][CH2:14][N:15]2C(=O)C3C(=CC=CC=3)C2=O)=[O:6])[CH2:3][CH2:2]1.O.NN>C(O)C>[NH2:15][CH2:14][CH2:13][CH2:12][C:11]1[N:10]([C:26]2[CH:27]=[CH:28][C:29]([C:32]([NH:34][CH2:35][CH3:36])=[O:33])=[CH:30][CH:31]=2)[N:9]=[N:8][C:7]=1[C:5]([NH:4][CH:1]1[CH2:3][CH2:2]1)=[O:6]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 57665168N-cyclopropyl-5-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide

Product 1

HCID 57665091HCID 57665091, compoundYield 97.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of N-cyclopropyl-5-[3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazole-4-carboxamide (1.27 g, 2.6 mmol) obtained in Example 1201 and hydrazine hydrate (261 mg, 5.2 mmol) in ethanol (20 ml) was boiled under reflux for 3 hr, and the precipitated insoluble material was filtered off. The filtrate was concentrated to dryness to give the title compound as a white powder (0.9 g, 97%).

Workup

  1. temperatureunder reflux for 3 hr
  2. filtrationthe precipitated insoluble material was filtered off
  3. concentrationThe filtrate was concentrated to dryness

Sources & evidence

ORD record
ord-d861c19a0ca0401f8a2f7bc53cee0f77
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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