反应详情

A solution of (4-[(cyclopropylamino)carbonyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazol-5-yl)propyl methanesulfonate (1.31 g, 3 mmol) obtained in Example 1201a) and potassium cyanide (235 mg, 3.6 mmol, 1.2 eq.) in DMSO (10 ml) was stirred for 15 hr, ice water (20 ml) was added, and the precipitated crystals were collected by filtration and dried to give the title compound as a colorless powder (925 mg, 84%).

1. filtrationthe precipitated crystals were collected by filtration
2. customdried