Potassium Cyanide → HCID 57665055, compound

HRID 1717416Notes

Reaction equation

HRID 1717416 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]1[N:13]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][CH3:24])=[O:21])=[CH:16][CH:15]=2)[N:12]=[N:11][C:10]=1[C:25]([NH:27][CH:28]1[CH2:30][CH2:29]1)=[O:26])(=O)=O.[C-:31]#[N:32].[K+]>CS(C)=O>[C:31]([CH2:6][CH2:7][CH2:8][C:9]1[N:13]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([NH:22][CH2:23][CH3:24])=[O:21])=[CH:16][CH:15]=2)[N:12]=[N:11][C:10]=1[C:25]([NH:27][CH:28]1[CH2:30][CH2:29]1)=[O:26])#[N:32]

Participants

4

Reactant 2

HCID 9032Potassium CyanideHCID 86629814(4-[(cyclopropylamino)carbonyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazol-5-yl)propyl methanesulfonate

Product 1

HCID 57665055HCID 57665055, compoundYield 84.1%

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

A solution of (4-[(cyclopropylamino)carbonyl]-1-{4-[(ethylamino)carbonyl]phenyl}-1H-1,2,3-triazol-5-yl)propyl methanesulfonate (1.31 g, 3 mmol) obtained in Example 1201a) and potassium cyanide (235 mg, 3.6 mmol, 1.2 eq.) in DMSO (10 ml) was stirred for 15 hr, ice water (20 ml) was added, and the precipitated crystals were collected by filtration and dried to give the title compound as a colorless powder (925 mg, 84%).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. customdried

Sources & evidence

ORD record
ord-1bc9f52c077344efbd8a517bb5f670ac
Source dataset
uspto-grants-2010_09
Patent number
US07803822B2

Reaction notes

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