Triethylamine → 4-Cyano-3-fluorobenzyl methanesulfonate

HRID 1717491Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1717491
[F:1][C:2]1[CH:9]=[C:8]([CH2:10][OH:11])[CH:7]=[CH:6][C:3]=1[C:4]#[N:5].C(N(CC)CC)C.[CH3:19][S:20](Cl)(=[O:22])=[O:21]>C(Cl)Cl>[CH3:19][S:20]([O:11][CH2:10][C:8]1[CH:7]=[CH:6][C:3]([C:4]#[N:5])=[C:2]([F:1])[CH:9]=1)(=[O:22])=[O:21]

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 118296312-Fluoro-4-(hydroxymethyl)benzonitrile

Produkt 1

HCID 219046204-Cyano-3-fluorobenzyl methanesulfonate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-Fluoro-4-hydroxymethylbenzonitrile (1.3 g, 8.6 mmol; see step (ii) above) was dissolved in 50 mL of CH2Cl2 and cooled on an ice bath. Triethylamine (0.87 g, 8.6 mmol) and methanesulfonyl chloride (0.99 g, 8.7 mmol) were added. After stirring for 1.5 h the reaction mixture washed with 1M HCl. The organic phase was dried (Na2SO4) and evaporated. The product could be used without purification. Yield of a colourless oil: 1.8 g (92%).

Aufarbeitung

  1. temperaturecooled on an ice bath
  2. washwashed with 1M HCl
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. customevaporated
  5. customThe product could be used without purification

Quellen und Nachweise

ORD-Eintrag
ord-88a93786023543c29600724716f84d45
Quelldatensatz
uspto-grants-2010_09
Patentnummer
US07803954B2

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