HRID1717519

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID44126830

N-(5-fluoro-2-phenoxyphenyl)acetamide

C14H12FNO2

结构：COc1ccc(OCCO[Si](C(C)C)(C(C)C)C(C)C)c(CBr)c1

HCID59765852

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(OCCO[Si](C(C)C)(C(C)C)C(C)C)c(CN(C(C)=O)c2cc(F)ccc2Oc2ccccc2)c1

HCID24785553

未命名化合物

收率 56%

PROCEDURE

实验过程

The general procedure C was applied to N-(5-Fluoro-2-phenoxy-phenyl)-acetamide and 9b. The desired compound 9c was obtained in 56% yield (3.27 g; 5.61 mmol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-07df11d8d507416f98b01edb72d4fd19
来源数据集: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07803960B2
来源说明: uspto-grants-2010_09

反应 SMILES

[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:7]=1.Br[CH2:20][C:21]1[CH:40]=[C:39]([O:41][CH3:42])[CH:38]=[CH:37][C:22]=1[O:23][CH2:24][CH2:25][O:26][Si:27]([CH:34]([CH3:36])[CH3:35])([CH:31]([CH3:33])[CH3:32])[CH:28]([CH3:30])[CH3:29]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([N:8]([CH2:20][C:21]2[CH:40]=[C:39]([O:41][CH3:42])[CH:38]=[CH:37][C:22]=2[O:23][CH2:24][CH2:25][O:26][Si:27]([CH:34]([CH3:36])[CH3:35])([CH:28]([CH3:30])[CH3:29])[CH:31]([CH3:33])[CH3:32])[C:9](=[O:11])[CH3:10])[CH:7]=1