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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1717519Generated: October 31, 2026

N-(5-fluoro-2-phenoxyphenyl)acetamide → N-(5-Fluoro-2-phenoxy-phenyl)-N-[5-methoxy-2-(2-triisopropylsilanyloxy-ethoxy)-benzyl]-acetamide

https://huagongshe.com/reaction/1717519

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(5-fluoro-2-phenoxyphenyl)acetamideHCID 44126830—
Reactant[2-(2-Bromomethyl-4-methoxy-phenoxy)-ethoxy]-triisopropyl-silaneHCID 59765852—
ProductN-(5-Fluoro-2-phenoxy-phenyl)-N-[5-methoxy-2-(2-triisopropylsilanyloxy-ethoxy)-benzyl]-acetamideHCID 2478555356%

Reaction Steps

The general procedure C was applied to N-(5-Fluoro-2-phenoxy-phenyl)-acetamide and 9b. The desired compound 9c was obtained in 56% yield (3.27 g; 5.61 mmol).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07803960B2
Source datasetuspto-grants-2010_09
ORD IDord-07df11d8d507416f98b01edb72d4fd19
Source noteuspto-grants-2010_09