N-(5-fluoro-2-phenoxyphenyl)acetamide → N-[2-(2-Allyloxy-ethoxy)-5-methoxy-benzyl]-N-(5-fluoro-2-phenoxy-phenyl)-acetamide

HRID 1717520Notes

Reaction equation

HRID 1717520 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[C:6]([NH:8][C:9](=[O:11])[CH3:10])[CH:7]=1.[CH2:19]([O:22][CH2:23][CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=1[CH2:34]Br)[CH:20]=[CH2:21]>>[CH2:19]([O:22][CH2:23][CH2:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][C:27]=1[CH2:34][N:8]([C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[CH:4][C:5]=1[O:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:9](=[O:11])[CH3:10])[CH:20]=[CH2:21]

Participants

3

Reactant 2

HCID 44126830N-(5-fluoro-2-phenoxyphenyl)acetamideHCID 671040421-(2-Allyloxy-ethoxy)-2-bromomethyl-4-methoxy-benzene

Product 1

HCID 24785555N-[2-(2-Allyloxy-ethoxy)-5-methoxy-benzyl]-N-(5-fluoro-2-phenoxy-phenyl)-acetamideYield 49%

Procedure

The general procedure C was applied to N-(5-Fluoro-2-phenoxy-phenyl)-acetamide and 10b The desired product 10c was obtained in 49% yield (4.9 mmol; 2.28 g).

Workup

  1. customwas obtained in 49% yield (4.9 mmol; 2.28 g)

Sources & evidence

ORD record
ord-08b6c0e97f3c47ad8bcb6965be15f53c
Source dataset
uspto-grants-2010_09
Patent number
US07803960B2

Reaction notes

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