HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Verapamil | HCID 2520 | — |
| Product | 2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile--hydrogen chloride (1/1) | HCID 170014 | — |
Reaction Steps
The verapamil base was released from the salt using an inorganic base and converted directly into the corresponding hydrochloride. 9.9 g of (R)-verapamil hydrochloride were obtained with an enantiomeric purity=99.66%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07803962B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-2160107397ca425a9764d14df6c4f4fa |
| Source note | uspto-grants-2010_09 |