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HRID1717640

反应详情

EQUATION

反应方程式

HRID 1717640 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：COc1ccc(CCN(C)CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC
HCID2520

(+/-)-Verapamil

C27H38N2O4

PRODUCTS

生成物

1
结构：COc1ccc(CCN(C)CCC[C@](C#N)(c2ccc(OC)c(OC)c2)C(C)C)cc1OC.Cl
HCID170014

2-(3,4-Dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile--hydrogen chloride (1/1)

C27H39ClN2O4

PROCEDURE

实验过程

The verapamil base was released from the salt using an inorganic base and converted directly into the corresponding hydrochloride. 9.9 g of (R)-verapamil hydrochloride were obtained with an enantiomeric purity=99.66%.