Hydrogen chloride-ethyl acetate → 2-methyl-3-[(1-methyl-1H-indazol-3-yl)methyl]-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one hydrochloride

HRID 1718833Notes

Reaction equation

HRID 1718833 reaction equation
[CH3:1][C:2]1[N:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH3:18])[N:10]=2)[C:6](=[O:19])[C:5]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[NH:37][C:36](=[O:38])[O:35][N:34]=3)=[CH:23][CH:22]=2)=[C:4]([CH2:39][CH2:40][CH3:41])[N:3]=1.[ClH:42].C(OCC)(=O)C>C(OCC)(=O)C>[ClH:42].[CH3:1][C:2]1[N:7]([CH2:8][C:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[N:11]([CH3:18])[N:10]=2)[C:6](=[O:19])[C:5]([CH2:20][C:21]2[CH:26]=[CH:25][C:24]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][C:28]=3[C:33]3[NH:37][C:36](=[O:38])[O:35][N:34]=3)=[CH:23][CH:22]=2)=[C:4]([CH2:39][CH2:40][CH3:41])[N:3]=1

Participants

4

Reactant 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 1360268612-methyl-3-[(1-methyl-1H-indazol-3-yl)methyl]-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one

Product 1

HCID 1362033572-methyl-3-[(1-methyl-1H-indazol-3-yl)methyl]-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one hydrochlorideYield 83%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 2-methyl-3-[(1-methyl-1H-indazol-3-yl)methyl]-5-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one (0.38 g) and ethyl acetate (10 mL) was added 4 M hydrochloric acid-ethyl acetate (0.19 mL) at room temperature. The obtained crystallized product was collected by filtration to give the title compound as colorless crystals (0.33 g, 83%).

Workup

  1. customThe obtained crystallized product
  2. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-1d5bdfd4419a4c209871fb2c69151432
Source dataset
uspto-grants-2010_09
Patent number
US07803940B2

Reaction notes

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