HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → 3-Amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | HCID 13375105 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 3-Amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one | HCID 357334 | — |
Reaction Steps
14 ml of a 25% solution of hydrogen bromide in acetic acid was added to 3.0 g of 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one and the resulting mixture was stirred at room temperature for an hour. After the addition of ether, the precipitated crystals were separated by filtration to obtain 2.45 g of the hydrobroxide of the desired compound, or 3-amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one. Its melting point was 290° C. or above.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539151 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-d89896f7d4b345d8a00eb180e4b2ddbb |
| Source note | uspto-grants-1985_09 |