Hydrogen Bromide → 3-Amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

HRID 1719104Notes

Reaction equation

HRID 1719104 reaction equation
Br.C(OC([NH:12][CH:13]1[C:19](=[O:20])[NH:18][C:17]2[CH:21]=[CH:22][CH:23]=[CH:24][C:16]=2[S:15][CH2:14]1)=O)C1C=CC=CC=1.CCOCC>C(O)(=O)C>[NH2:12][CH:13]1[C:19](=[O:20])[NH:18][C:17]2[CH:21]=[CH:22][CH:23]=[CH:24][C:16]=2[S:15][CH2:14]1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 133751053-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Product 1

HCID 3573343-Amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

14 ml of a 25% solution of hydrogen bromide in acetic acid was added to 3.0 g of 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one and the resulting mixture was stirred at room temperature for an hour. After the addition of ether, the precipitated crystals were separated by filtration to obtain 2.45 g of the hydrobroxide of the desired compound, or 3-amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one. Its melting point was 290° C. or above.

Workup

  1. customthe precipitated crystals were separated by filtration

Sources & evidence

ORD record
ord-d89896f7d4b345d8a00eb180e4b2ddbb
Source dataset
uspto-grants-1985_09
Patent number
US04539151

Reaction notes

Loading…