3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one → 3-Amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

HRID 1719105Notes

Reaction equation

HRID 1719105 reaction equation
C(OC([NH:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH2:13]1)=O)C1C=CC=CC=1>CO.[C].[Pd]>[NH2:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH2:13]1

Participants

4

Reactant 1

HCID 133751053-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Product 1

HCID 3573343-Amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Reagents, catalysts & solvents 2

HCID 178418390HCID 178418390, compoundCatalystHCID 887MethanolSolvent

Procedure

1.0 g of 3-benzyloxycarbonylamino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one was dissolved in 20 ml of methanol and then hydrogenated at atmospheric pressure in the presence of 50 mg of 5% palladium-carbon. Thus, there was obtained the desired compound, or 3-amino-2,3-dihydro-1,5-benzothiazepin-4(5H)-one.

Sources & evidence

ORD record
ord-ca91a323ecab4a5f8a1d788457d863e8
Source dataset
uspto-grants-1985_09
Patent number
US04539151

Reaction notes

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