Hydrogen Bromide → 3-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide

HRID 1719116Notes

Reaction equation

HRID 1719116 reaction equation
C(OC([NH:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH:13]1[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=O)C1C=CC=CC=1.CCOCC.[BrH:35]>C(O)(=O)C>[BrH:35].[NH2:11][CH:12]1[C:18](=[O:19])[NH:17][C:16]2[CH:20]=[CH:21][CH:22]=[CH:23][C:15]=2[S:14][CH:13]1[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

Participants

5

Reactant 3

HCID 260Hydrogen BromideHCID 3283Diethyl EtherHCID 134905083-benzyloxycarbonylamino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Product 1

HCID 199935893-amino-2-phenyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one hydrobromide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

5.4 g of the compound obtained in Example 2 was dissolved in a 25% solution of hydrogen bromide in acetic acid. After the lapse of 2 hours, 15 ml of acetic acid was added to the solution and the resulting mixture was stirred for an hour. After the addition of ether, the precipitated crystals were separated by filtration and washed with ether to obtain 4.0 g of the desired compound.

Workup

  1. customthe precipitated crystals were separated by filtration
  2. washwashed with ether

Sources & evidence

ORD record
ord-7288c878400646f29737b69e45b98104
Source dataset
uspto-grants-1985_09
Patent number
US04539150

Reaction notes

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