Ethyl alpha-oxobenzenebutanoate → HCID 13454545, compound

HRID 1719120Notes

Reaction equation

HRID 1719120 reaction equation
[NH2:1][CH:2]1[C:8](=[O:9])[N:7]([CH2:10][C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[C:6]2[CH:18]=[CH:19][CH:20]=[CH:21][C:5]=2[S:4][CH2:3]1.[CH2:22]([CH2:29][C:30](=O)[C:31]([O:33][CH2:34][CH3:35])=[O:32])[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1>>[C:14]([O:13][C:11]([CH2:10][N:7]1[C:6]2[CH:18]=[CH:19][CH:20]=[CH:21][C:5]=2[S:4][CH2:3][CH:2]([NH:1][CH:30]([C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:29][CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[C:8]1=[O:9])=[O:12])([CH3:16])([CH3:17])[CH3:15]

Participants

3

Reactant 2

HCID 562087Ethyl alpha-oxobenzenebutanoateHCID 134545423-amino-5-t-butoxycarbonylmethyl-2,3-dihydro-1,5-benzothiazepin-4(5H)-one

Product 1

HCID 13454545HCID 13454545, compound

Procedure

The compound obtained in Example 7 was reacted with ethyl benzylpyruvate in the same manner as described in Example 9. Thus, there was obtained 5-t-butoxycarbonylmethyl-3-(1-ethoxycarbonyl-3-phenylpropylamino)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one in the form of an oily material.

Sources & evidence

ORD record
ord-cfb2600d47cc4076b916afcc8900f403
Source dataset
uspto-grants-1985_09
Patent number
US04539150

Reaction notes

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