Sodium Methoxide → HCID 20267867, compound

HRID 1719206Notes

Reaction equation

HRID 1719206 reaction equation
Br[C:2]1[C:3](=[O:14])[NH:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][N:9]=2)[CH:7]=1.C[O-:16].[Na+]>CO>[OH:16][C:2]1[C:3](=[O:14])[NH:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][N:11]=[CH:10][N:9]=2)[CH:7]=1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 132766783-Bromo-5-(pyrimidin-4-yl)pyridin-2(1H)-one

Product 1

HCID 20267867HCID 20267867, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5.0 g of 3-bromo-5-(4-pyrimidinyl)-2-(1H)-pyridone, 6.0 g of sodium methoxide and 100 ml of methanol is autoclaved at 200° for twelve hours. The solvent is distilled off in vacuo and the residue treated with water. The aqueous mixture is neutralized with acetic acid and the resulting solid collected, washed with water and dried. Recrystallization from dimethylformamide with a hot filtration yields the desired product.

Workup

  1. waitis autoclaved at 200° for twelve hours
  2. distillationThe solvent is distilled off in vacuo
  3. additionthe residue treated with water
  4. customthe resulting solid collected
  5. washwashed with water
  6. customdried
  7. customRecrystallization from dimethylformamide
  8. filtrationwith a hot filtration

Sources & evidence

ORD record
ord-49d78de94d2b47a2bea1da787848236a
Source dataset
uspto-grants-1985_09
Patent number
US04539321

Reaction notes

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