HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → HCID 20267867, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-Bromo-5-(pyrimidin-4-yl)pyridin-2(1H)-one | HCID 13276678 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 20267867 | HCID 20267867 | — |
Reaction Steps
A mixture of 5.0 g of 3-bromo-5-(4-pyrimidinyl)-2-(1H)-pyridone, 6.0 g of sodium methoxide and 100 ml of methanol is autoclaved at 200° for twelve hours. The solvent is distilled off in vacuo and the residue treated with water. The aqueous mixture is neutralized with acetic acid and the resulting solid collected, washed with water and dried. Recrystallization from dimethylformamide with a hot filtration yields the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539321 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-49d78de94d2b47a2bea1da787848236a |
| Source note | uspto-grants-1985_09 |