HCID 13251293, compound → 6-Trifluoromethylisatin

HRID 1719232Notes

Reaction equation

HRID 1719232 reaction equation
[Cl:1][C:2]1[CH:28]=[C:27]([Br:29])[CH:26]=[CH:25][C:3]=1[CH2:4]N1C2C(=CC=C(C(F)(F)F)C=2)C2(C(=O)NC(=O)N2)C1=O.ClC1C=C([Br:53])C=CC=1C[N:34]1[C:42]2[C:37](=[CH:38][CH:39]=[C:40]([C:43]([F:46])([F:45])[F:44])[CH:41]=2)[C:36](=[O:47])[C:35]1=[O:48]>>[Cl:1][C:2]1[CH:28]=[C:27]([Br:29])[CH:26]=[CH:25][C:3]=1[CH2:4][Br:53].[F:46][C:43]([F:44])([F:45])[C:40]1[CH:41]=[C:42]2[C:37]([C:36](=[O:47])[C:35](=[O:48])[NH:34]2)=[CH:38][CH:39]=1

Participants

4

Reactant 2

HCID 13251293HCID 13251293, compoundHCID 13251297HCID 13251297, compound

Product 2

HCID 109876496-TrifluoromethylisatinHCID 219144864-Bromo-1-(bromomethyl)-2-chlorobenzene

Procedure

(Example 5): 1'-(2-chloro-4-bromobenzyl)-6'-trifluoromethyl-spiro[imidazolidine-4,3'-indoline]-2,2',5-trione, as a solid, m.p. 299°-301° C., starting from 1-(2-chloro-4-bromobenzyl)-6-trifluoromethylindoline-2,3-dione (itself obtained as a solid, m.p. 132°-134° C., by reaction of 2-chloro-4-bromobenzyl bromide with 6-trifluoromethylindoline-2,3-dione in an analogous manner to that described for the starting material in Example 1).

Sources & evidence

ORD record
ord-97f798d7bbc9499f9193e6d5bf1d9925
Source dataset
uspto-grants-1985_09
Patent number
US04539329

Reaction notes

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