HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloro-2(1H)-pyrimidinone → 5-Chloro-1-{[(4-methoxyphenyl)methoxy]methyl}pyrimidin-2(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloro-2(1H)-pyrimidinone | HCID 108578 | — |
| Reactant | 1-[(Chloromethoxy)methyl]-4-methoxybenzene | HCID 10921254 | — |
| Product | 5-Chloro-1-{[(4-methoxyphenyl)methoxy]methyl}pyrimidin-2(1H)-one | HCID 15650493 | 52% |
Reaction Steps
was prepared as described in Example 3 from chloromethyl 4-methoxybenzyl ether (see Preparation 4a and 4b) (10 mmol) and 5-chloropyrimidin-2-one (10 mmol) in 52% yield (1.45 g), m.p. 118° C. 1H NMR (CDCl3): δ3.77 (OMe), 4.57 (CH2Ph), 5.27 (CH2O), 6.6-7.3 (Ph), 7.63 and 8.35 (H-4, H-6, J 4 Hz). IR(KBr): 1670 cm1 (CO).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539324 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-be35768f98674b7ebfb9b4837c654aba |
| Source note | uspto-grants-1985_09 |