HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Chloropyrimidin-2-ol hydrochloride → 1-(3-Trifluoromethylbenzyloxy)methyl-5-chloropyrimidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Chloropyrimidin-2-ol hydrochloride | HCID 12648523 | — |
| Reactant | 1-((Chloromethoxy)methyl)-3-(trifluoromethyl)benzene | HCID 13140584 | — |
| Product | 1-(3-Trifluoromethylbenzyloxy)methyl-5-chloropyrimidin-2-one | HCID 15650494 | — |
Reaction Steps
was prepared as described in Example 3 from chloromethyl 3-trifluoromethyl-benzyl ether (see Preparation 6a and 6b) (10 mmol) and 5-chloropyrimidin-2-one hydrochloride (10 mmol) in 52%. (1.66 g) yield, m.p. 95° C. 1H NMR (CDCl3): δ4.77 (CH2Ph), 5.42 (CH2O), 7.3-7.7 (Ph), 7.82 and 8.55 (H-4, H-6, J 4 Hz). IR(KBr): 1660 cm-1 (CO).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04539324 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-0a7893dac825424a8848780db6244df1 |
| Source note | uspto-grants-1985_09 |