Water → HCID 10041022, compound

Participants

Reaction Steps

To a stirred mixture of 1.9 parts of (E)-1-[2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-imidazole mononitrate in a mixture of 50 parts of water and 75 parts of trichloromethane was added 1.0 part of potassium carbonate. The whole was stirred till a clear solution was obtained (pH 8-9). The organic layer was separated, dried, filtered and evaporated. The residue was converted into the hydrochloride salt in 4-methyl-2-pentanone, 2,2'-oxybispropane and 2-propanol. The salt was filtered off and dried, yielding 1.5 parts (86%) of (E)-1-[2-chloro-2-(2,4-dichlorophenyl)ethenyl]-1H-imidazole monohydrochloride; mp. 203.2° C. (compound 24).

Provenance & Evidence