HCID 13491506, compound → HCID 13491509, compound

HRID 1719259Notes

Reaction equation

HRID 1719259 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:22]=[CH:23][C:24]=1[O:25][CH3:26])[C:6]([CH2:8][CH2:9][C:10](=[O:21])[C:11]1[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C@H:6]2[CH2:8][CH2:9][C@H:10]([C:11]3[CH:16]=[CH:15][C:14]([O:17][CH3:18])=[C:13]([O:19][CH3:20])[CH:12]=3)[O:21]2)[CH:22]=[CH:23][C:24]=1[O:25][CH3:26]

Participants

4

Reactant 2

HCID 13491506HCID 13491506, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 13491509HCID 13491509, compoundYield 20.8%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3.0 g of 1,2-bis(3,4-dimethoxybenzoyl)ethane was reduced with 350 mg of lithium aluminum hydride in 50 ml THF at 0° C. for 1 hour and ambient temperature for 3 hours. After the usual workup, 2.8 g of white solid diol was recovered and dissolved in 50 ml of methylene chloride. The solution at 0° C. was treated with 1.2 g of triethylamine followed by 1.2 g of methane sulfonyl chloride and stirred under N2 until the starting diol disappears by TLC. At this point, 200 ml of ether was added and the organic layer washed with water, 3N HCl, 10% NaOH, water and dried over anhydrous sodium sulfate. The residue obtained by evaporation was chromatographed to recover the major spot (silica gel, ethyl acetate-hexane 30:70). Crystallization from 50 ml methylene chloride and 100 ml of hexane evaporated to a final volume of 100 ml gave 0.6 g of trans- 2,5-bis (3,4-dimethoxyphenyl)tetrahydrofuran, NMR (CDCl3 ):δ 1.9-2.5 (4H, m, 3-H, 4-H) 3.85 and 3.90 (each s, 6H, 2×OCH3), 5.24 (2H, t, J=6.6 Hz, 2-, 5-H), and 6.8-7.0 (6H, m, ArH), m.p. 114°-115° C. The second and third crops gave 1.1 g of crystalline product which contains a mixture of cis and trans isomers. Separation of the isomers was made on Partisil-10 column using hexane (80%), ethylacetate (20%) as eluting solvent. The NMR of the cis isomer (m.p. 92°-96° C.) is shown below.

Workup

  1. customAfter the usual workup, 2.8 g of white solid diol was recovered
  2. dissolutiondissolved in 50 ml of methylene chloride
  3. additionThe solution at 0° C. was treated with 1.2 g of triethylamine
  4. additionAt this point, 200 ml of ether was added
  5. washthe organic layer washed with water, 3N HCl, 10% NaOH, water
  6. dry with materialdried over anhydrous sodium sulfate
  7. customThe residue obtained by evaporation
  8. customwas chromatographed
  9. customto recover the major spot (silica gel, ethyl acetate-hexane 30:70)
  10. customCrystallization from 50 ml methylene chloride and 100 ml of hexane
  11. customevaporated to a final volume of 100 ml

Sources & evidence

ORD record
ord-6f61382872c747dbaaf0d447de066970
Source dataset
uspto-grants-1985_09
Patent number
US04539332

Reaction notes

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