1-(7-Carboxyhept-6-enyl)-2-(1-imidazolyl)-3-methylindole → 1-(7-Carboxyheptyl)-2-(1-imidazolyl)-3-methylindole

HRID 1719394Notes

Reaction equation

HRID 1719394 reaction equation
[C:1]([CH:4]=[CH:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH3:20])=[C:12]1[N:21]1[CH:25]=[CH:24][N:23]=[CH:22]1)([OH:3])=[O:2].[H][H]>C(O)C.[Pd]>[C:1]([CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:13]([CH3:20])=[C:12]1[N:21]1[CH:25]=[CH:24][N:23]=[CH:22]1)([OH:3])=[O:2]

Participants

5

Reactant 2

HCID 539527301-(7-Carboxyhept-6-enyl)-2-(1-imidazolyl)-3-methylindoleHCID 178418361HCID 178418361, compound

Product 1

HCID 134914381-(7-Carboxyheptyl)-2-(1-imidazolyl)-3-methylindole

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1-(7-Carboxyhept-6-enyl)-2-(1-imidazolyl)-3-methylindole (20 mg) is dissolved in 1 ml of absolute ethanol with a catalytic amount of 10% palladium on charcoal and hydrogenated at 1 atmosphere pressure. After one mole of hydrogen is consumed the catalyst is removed by filtration and washed with a few milliliters of ethanol. The combined filtrates are concentrated to yield the 1-(7-carboxyheptyl)-3-methyl-2-(1-imidazolyl)indole.

Workup

  1. customis removed by filtration
  2. washwashed with a few milliliters of ethanol
  3. concentrationThe combined filtrates are concentrated

Sources & evidence

ORD record
ord-90972f49d616455ca289ec3e4aa1686f
Source dataset
uspto-grants-1985_09
Patent number
US04539410

Reaction notes

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