反应详情

1-(5-Formylpentyl)-3-methyl-2-(1-imidazolyl)indole (115 mg) is dissolved in dimethylformamide (1.0 ml) and pyridinium dichromate (300 mg) added all at once. The mixture is stirred overnight at room temperature, then diluted with chloroform, and the combined filtrate is extracted with 0.1N aqueous sodium hydroxide (2 ml). The aqueous extract is acidified to about pH 5.5-6.0 and extracted with chloroform. The chloroform extract is dried and concentrated in vacuo. Purification by chromatography on silica gel yields 1-(5-carboxypentyl)-2-(1-imidazolyl)-3-methylindole.

1. extractionthe combined filtrate is extracted with 0.1N aqueous sodium hydroxide (2 ml)
2. extractionThe aqueous extract
3. extractionextracted with chloroform
4. extractionThe chloroform extract
5. customis dried
6. concentrationconcentrated in vacuo
7. customPurification by chromatography on silica gel