反应详情

Thionyl chloride (0.36 ml) is combined with 1-(6-hydroxyhexyl)-3-methyl-2-(1-imidazolyl)indole (1.3 g) at 0°. The mixture is then stirred at room temperature for 1 hour. Saturated aqueous sodium bicarbonate is added and the mixture is extracted with dichloromethane. The extract is washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. Concentration to dryness and purification by chromatography gives 1-(6-chlorohexyl)-3-methyl-2-(1-imidazolyl)indole.

1. extractionthe mixture is extracted with dichloromethane
2. washThe extract is washed with saturated sodium chloride solution
3. dry with materialdried over anhydrous magnesium sulfate
4. concentrationConcentration
5. customto dryness and purification by chromatography