Methyl iodide → 1-Methyl-3-{N-[beta-(4-pivalyloxyphenyl)ethyl]}carbamoylpyridinium iodide

Participants

Reaction Steps

To a solution of 1.63 g (5 mmol) of the product of Example 26 in 10 ml of acetone, 1.41 g (10 mmol) methyl iodide were added and the mixture was refluxed overnight while stirring. The acetone layer was separated by decantation and the yellowish, oily residue was crystallized from methanol/ether.

Provenance & Evidence