反应详情

A suspension of 16.4 g of 2-amino-4,6-dichloro-pyrimidine in 100 ml of 40% sodium hydroxide solution is stirred for 1 hour at a temperature of 95° to 100° C. After the addition of 200 ml of dioxane, there are added at a temperature of 70° to 75° C., within 1 hour, 20 g of gaseous difluoromethane. The organic phase is separated, and concentrated to about 1/5 of its volume; it is then poured into water and the solid precipitate is removed. The yield is 6 g of 2-amino-4-chloro-6-difluoromethoxy-pyrimidine, m.p. 118° to 119° C. (compound No. 1.7).

1. additionare added at a temperature of 70° to 75° C., within 1 hour
2. customThe organic phase is separated
3. concentrationconcentrated to about 1/5 of its volume
4. additionit is then poured into water
5. customthe solid precipitate is removed