HCID 53824855, compound → HCID 20266259, compound

HRID 1719662Notes

Reaction equation

HRID 1719662 reaction equation
[C:1]1([C:7]2[CH:19]=[CH:18][C:10]([C:11]([CH:13]=[CH:14][C:15]([OH:17])=[O:16])=[S:12])=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:20]([OH:23])(=[S:22])[CH3:21]>C(Cl)(Cl)Cl>[C:20]([S:22][CH:14]([CH2:13][C:11](=[S:12])[C:10]1[CH:18]=[CH:19][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[CH:8][CH:9]=1)[C:15]([OH:17])=[O:16])(=[O:23])[CH3:21]

Participants

4

Reactant 2

HCID 53824855HCID 53824855, compoundHCID 178418634HCID 178418634, compound

Product 1

HCID 20266259HCID 20266259, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

To a solution of 2.84 g of 3-(4-phenylthiobenzoyl)acrylic acid in 30 ml of chloroform was added 0.8 ml of thioacetic acid, and the resulting mixture was stirred for 5 hours at room temperature. The chloroform was removed from the mixture by evaporation under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate) and then recrystallized from a mixture of hexane and ethyl acetate to give 3.24 g of 2-acetylthio-3-(4-phenylthiobenzoyl)propionic acid.

Workup

  1. customThe chloroform was removed from the mixture by evaporation under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (eluent: hexane-ethyl acetate)
  3. customrecrystallized from a mixture of hexane and ethyl acetate

Sources & evidence

ORD record
ord-b5f1711ff265436a8bee6c65c8bb6162
Source dataset
uspto-grants-1985_09
Patent number
US04541959

Reaction notes

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