2-(Diisopropylamino)ethyl chloride → 4-Diisopropylamino 2-(2-pyridyl)butyronitrile

Participants

Reaction Conditions

Reaction Steps

8 g of 2-pyridyl acetonitrile, 8.8 g of 1-chloro 2-diisopropylamino ethane and 0.27 g of benzyltrimethylammonium chloride are mixed, then, maintaining the temperature below 35° C., 35 ml of 50% sodium hydroxide solution are added. The mixture is heated to 35° C. for 5 hours. After cooling, it is diluted with water and extracted with ether. The organic phase is separated and dried over sodium sulfate, then the solvent is evaporated to dryness.

Provenance & Evidence