Sodium Hydroxide → HCID 20266533, compound

HRID 1719697Notes

Reaction equation

HRID 1719697 reaction equation
Cl.Cl.[N:3]1([CH2:8][CH2:9][NH2:10])[CH:7]=[N:6][CH:5]=[N:4]1.[OH-].[Na+].[Cl:13][C:14]1[C:15]2[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=2[S:17][C:18]=1[C:19](Cl)=[O:20]>C(Cl)Cl>[Cl:13][C:14]1[C:15]2[CH:25]=[CH:24][CH:23]=[CH:22][C:16]=2[S:17][C:18]=1[C:19]([NH:10][CH2:9][CH2:8][N:3]1[CH:7]=[N:6][CH:5]=[N:4]1)=[O:20]

Participants

5

Reactant 3

HCID 14798Sodium Hydroxide2×HCID 5198983-Chlorobenzo(b)thiophene-2-carbonyl chlorideHCID 202483172-(1H-1,2,4-Triazol-1-yl)ethan-1-amine--hydrogen chloride (1/2)

Product 1

HCID 20266533HCID 20266533, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of about 1.85 g of 1H-1,2,4-triazole-1ethanamine dihydrochloride, about 50 ml of methylene chloride, about 30 ml of 1N sodium hydroxide and about 2.3 g of 3-chlorobenzo-[b]thiophene carbonyl chloride was stirred for about 16 hours. A 50 ml portion of methylene chloride and about 5 ml of 1N sodium hydroxide were added and the layers were separated. The organic layer was washed twice with water dried and concentrated, giving the desired compound, mp 151°-152° C.

Workup

  1. customthe layers were separated
  2. washThe organic layer was washed twice with water
  3. customdried
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-a92851b8014b407a8efc7ee0a115814c
Source dataset
uspto-grants-1985_09
Patent number
US04542145

Reaction notes

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