HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1R,cis)2,2-dimethyl-3-[(Z)3-oxo-3-(2,2,2-trifluoroethoxy)-1-propenyl]-cyclopropane-carboxylic acid → (R)alpha-ethynyl-3-phenoxy-benzyl (1R,cis) 2,2-dimethyl-3[(Z) 3-oxo-3(2,2,2-trifluoroethoxy)-1-propenyl]-cyclopropane-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1R,cis)2,2-dimethyl-3-[(Z)3-oxo-3-(2,2,2-trifluoroethoxy)-1-propenyl]-cyclopropane-carboxylic acid | HCID 13390085 | — |
| Reactant | (R)alpha-ethynyl-3-phenoxy-benzyl alcohol | HCID 53829177 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | (R)alpha-ethynyl-3-phenoxy-benzyl (1R,cis) 2,2-dimethyl-3[(Z) 3-oxo-3(2,2,2-trifluoroethoxy)-1-propenyl]-cyclopropane-carboxylate | HCID 131714332 | — |
Reaction Steps
Using the orocedure of Step F of Example 9, the acid of Step D of Example 1 and (R)α-ethynyl-3-phenoxy-benzyl alcohol were reacted to obtain (R)α-ethynyl-3-phenoxy-benzyl (1R,cis) 2,2-dimethyl-3[(Z) 3-oxo-3(2,2,2-trifluoroethoxy)-1-propenyl]-cyclopropane-carboxylate with a specific rotation of [α]D20 =+42°±1.5° (c=1% in CHCl3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04542142 |
| Source dataset | uspto-grants-1985_09 |
| ORD ID | ord-3aa903c2e78b4f8d9336e2b7a0fa6b73 |
| Source note | uspto-grants-1985_09 |