Hydroxide → 4-(2,5-Difluoro-4-aminophenoxy)-3-iodo-2-[bis[(1,1-dimethylethoxy)carbonyl]amino]pyridine

HRID 171982Notes

Reaction equation

HRID 171982 reaction equation
[CH3:35][CH2:36][O:37][C:38]([CH3:39])=[O:40].[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]([I:26])[c:7]([N:11]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[n:8][cH:9][cH:10]2)[cH:27][c:28]([F:34])[c:29]([N+:31]([O-:32])=[O:33])[cH:30]1.[OH-:41].[OH-:43].[Pd+2:42]>>[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]([I:26])[c:7]([N:11]([C:12](=[O:13])[O:14][C:15]([CH3:16])([CH3:17])[CH3:18])[C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[n:8][cH:9][cH:10]2)[cH:27][c:28]([F:34])[c:29]([NH2:31])[cH:30]1

Participants

5

Reactant 4

HCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 680094134-(2,5-Difluoro-4-nitrophenoxy)-3-iodo-2-[bis[(1,1-dimethylethoxy)-carbonyl]amino]pyridine

Product 1

HCID 680094164-(2,5-Difluoro-4-aminophenoxy)-3-iodo-2-[bis[(1,1-dimethylethoxy)carbonyl]amino]pyridine

Sources & evidence

ORD record
ord-ff6b091785234969a9e715a196f88c30
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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