2-Phenyl-1-(1H-pyrrol-2-yl)ethan-1-one → HCID 13220943, compound

HRID 1719879Notes

Reaction equation

HRID 1719879 reaction equation
[C:1]1([CH2:7][C:8]([C:10]2[NH:11][CH:12]=[CH:13][CH:14]=2)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[CH2:8]([C:10]1[NH:11][CH:12]=[CH:13][CH:14]=1)[CH2:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 134470562-Phenyl-1-(1H-pyrrol-2-yl)ethan-1-oneHCID 21226445Aluminium lithium hydride

Product 1

HCID 13220943HCID 13220943, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Compound (III) is dissolved in an ethereal solvent, preferably anhydrous tetrahydrofuran, and a complex metal hydride, preferably lithium aluminum hydride, is added. The mixture is reacted at reflux temperature for 35-53 hours, preferably 48 hours. Excess of hydride is destroyed with organic solvent and the reaction mixture is purified by methods known to the art to afford 2-[phenethyl]pyrrole (IV).

Workup

  1. customThe mixture is reacted
  2. temperatureat reflux temperature for 35-53 hours
  3. custompreferably 48 hours
  4. customExcess of hydride is destroyed with organic solvent
  5. customthe reaction mixture is purified by methods

Sources & evidence

ORD record
ord-f0567ab360e6480fb6e0d0905e5cf1ce
Source dataset
uspto-grants-1985_09
Patent number
US04543361

Reaction notes

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