Hydrochloric Acid → HCID 20266123, compound

HRID 1719884Notes

Reaction equation

HRID 1719884 reaction equation
[ClH:1].[CH2:2]([CH:10]1[CH2:14][CH2:13][CH:12]([CH:15]([OH:25])[C:16]2[CH:21]=[CH:20][C:19]3[O:22][CH2:23][O:24][C:18]=3[CH:17]=2)[NH:11]1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.C(OCC)C>CO>[ClH:1].[CH2:2]([CH:10]1[CH2:14][CH2:13][CH:12]([CH:15]([OH:25])[C:16]2[CH:21]=[CH:20][C:19]3[O:22][CH2:23][O:24][C:18]=3[CH:17]=2)[NH:11]1)[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 9905364HCID 9905364, compound

Product 1

HCID 20266123HCID 20266123, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

Excess 3% hydrogen chloride in methanol is added to a solution of 1.0 g of ±2-[phenethyl]-5-[(3,4-methylenedioxy)-α-hydroxybenzyl]pyrrolidine in 20 ml of methanol. Diethyl ether is added until precipitation is complete. ±2-[phenethyl]-5-[(3,4-methylenedioxy)-α-hydroxybenzyl]pyrrolidine hydrochloride is filtered, washed with ether, air dried and recrystallized.

Workup

  1. filtration±2-[phenethyl]-5-[(3,4-methylenedioxy)-α-hydroxybenzyl]pyrrolidine hydrochloride is filtered
  2. washwashed with ether, air
  3. customdried
  4. customrecrystallized

Sources & evidence

ORD record
ord-91da42b2961e485fa5e11487c83e9237
Source dataset
uspto-grants-1985_09
Patent number
US04543361

Reaction notes

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