Diphenyl Ether → HCID 13060553, compound

HRID 1719951Notes

Reaction equation

HRID 1719951 reaction equation
CO[C:3](=[O:26])[C:4](=[CH:9][NH:10][C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])[CH:19]=2)[N:14]=[CH:13][N:12]=1)[C:5]([O:7][CH3:8])=[O:6].C1(OC2C=CC=CC=2)C=CC=CC=1>>[O:26]=[C:3]1[N:12]2[CH:13]=[N:14][C:15]3[CH:16]=[CH:17][C:18]([NH:21][S:22]([CH3:25])(=[O:24])=[O:23])=[CH:19][C:20]=3[C:11]2=[N:10][CH:9]=[C:4]1[C:5]([O:7][CH3:8])=[O:6]

Participants

3

Reactant 2

HCID 7583Diphenyl EtherHCID 13060505HCID 13060505, compound

Product 1

HCID 13060553HCID 13060553, compoundYield 71.6%

Conditions

Temperature
250 °C

Procedure

A mixture of dimethyl[(6-methanesulfonamido-4-quinazolinylamino)methylene]propanedioate (7.2 g) and diphenyl ether (43 ml) was stirred at 250° C. for 15 minutes and then cooled to ambient temperature to give crystals, which were filtered off and washed with a mixture of chloroform and methanol to give crystalline methyl 4-oxo-10-methanesulfonamido-4H-pyrimido[1,2-c]quinazoline-3-carboxylate (4.72 g).

Workup

  1. temperaturecooled to ambient temperature
  2. customto give crystals, which
  3. filtrationwere filtered off
  4. washwashed with a mixture of chloroform and methanol

Sources & evidence

ORD record
ord-a72f20e90ea64b8d9a9c23c535fb7938
Source dataset
uspto-grants-1985_09
Patent number
US04543356

Reaction notes

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