Diphenyl Ether → HCID 13060557, compound

HRID 1719959Notes

Reaction equation

HRID 1719959 reaction equation
[CH3:1][O:2][C:3](=[O:30])[C:4](=[CH:9][NH:10][C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[C:18]([NH:21][C:22]([CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)=[O:23])[CH:19]=2)[N:14]=[CH:13][N:12]=1)[C:5](OC)=[O:6].C1(OC2C=CC=CC=2)C=CC=CC=1>>[O:6]=[C:5]1[N:12]2[CH:13]=[N:14][C:15]3[CH:16]=[CH:17][C:18]([NH:21][C:22]([CH:24]4[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]4)=[O:23])=[CH:19][C:20]=3[C:11]2=[N:10][CH:9]=[C:4]1[C:3]([O:2][CH3:1])=[O:30]

Participants

3

Reactant 2

HCID 7583Diphenyl EtherHCID 70484631HCID 70484631, compound

Product 1

HCID 13060557HCID 13060557, compoundYield 97.6%

Conditions

Temperature
260 °C

Procedure

A mixture of dimethyl[[6-cyclohexanecarboxamido-4-quinazolinylamino]methylene]propanedioate (4 g) and diphenyl ether (31 ml) was stirred at 260° C. for 15 minutes. After cooling to ambient temperature, the resulting solid was collected by filtration, washed with hexane and dried. There was obtained methyl 4-oxo-10-cyclohexanecarboxamido-4H-pyrimido[1,2-C]quinazoline-3-carboxylate (3.6 g).

Workup

  1. temperatureAfter cooling to ambient temperature
  2. filtrationthe resulting solid was collected by filtration
  3. washwashed with hexane
  4. customdried

Sources & evidence

ORD record
ord-0fced139a80d4630b3a4752d1d5101a5
Source dataset
uspto-grants-1985_09
Patent number
US04543356

Reaction notes

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