反应详情

2-Amino-N-methyl-benzylamine (3.7 g;27mmol) and sulfamide (5.2 g: 54 mmol) were dissolved in pyridine (40 ml). Mixture was refluxed for 3 hours, then the solvent was removed in vacuo, and water (50 ml) was added. Reaction mixture was extracted with ethyl acetate. Extract was dried over magnesium sulfate and solvent was evaporated off. Crude product was recrystallized from chloroform-hexane, to give the product, (4.4 g).

1. temperatureMixture was refluxed for 3 hours
2. customthe solvent was removed in vacuo, and water (50 ml)
3. additionwas added
4. customReaction mixture
5. extractionwas extracted with ethyl acetate
6. extractionExtract
7. dry with materialwas dried over magnesium sulfate and solvent
8. customwas evaporated off
9. customCrude product was recrystallized from chloroform-hexane
10. customto give the product, (4.4 g)