Diethyl Ether → HCID 4313443, compound

Selenium dioxide (35.5 g; 320 mmol) was dissolved in 250 mL of MeOH (warm to reflux with stirring), and 19.6 g (315 mmol) of α-bromo-4-chloroacetophenone was added. The reaction mixture was warmed to reflux for 24 hours, cooled, filtered and concentrated leaving an orange oil. The oil was diluted with 1500 mL of Et2O and washed three times with 200 mL of H2O and once with 200 mL of brine, dried (Na2SO4) and concentrated. The crude oil was crystallized from Et2O and hexanes at -20° C. The white needles were filtered while cold and washed with small portions of cold hexanes to yield 22 g (35%) of methyl p-chlorophenyl-α-oxoacetate,

1. temperatureThe reaction mixture was warmed
2. temperatureto reflux for 24 hours
3. temperaturecooled
4. filtrationfiltered
5. concentrationconcentrated
6. customleaving an orange oil
7. washwashed three times with 200 mL of H2O
8. dry with materialonce with 200 mL of brine, dried (Na2SO4)
9. concentrationconcentrated
10. customThe crude oil was crystallized from Et2O and hexanes at -20° C
11. filtrationThe white needles were filtered while cold and
12. washwashed with small portions of cold hexanes

ORD record

ord-e7efb6a3962143bcafcfd4985a2bcec8

Source dataset

uspto-grants-1996_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05504108