HCID 54488363, compound → HCID 54164563, compound

HRID 1720187Notes

Reaction equation

HRID 1720187 reaction equation
C([O:8][C:9](=[O:29])[C@H:10]([CH:26]([CH3:28])[CH3:27])[NH:11][CH2:12][CH:13]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)C1C=CC=CC=1>C(O)C.[Pd]>[CH2:24]([O:23][C:21]([CH:13]([CH2:14][C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1)[CH2:12][NH:11][C@H:10]([C:9]([OH:29])=[O:8])[CH:26]([CH3:28])[CH3:27])=[O:22])[CH3:25]

Participants

4

Reactant 1

HCID 54488363HCID 54488363, compound

Product 1

HCID 54164563HCID 54164563, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

2.4 g of N-(2-ethoxycarbonyl-3-phenylpropyl)-L-valine benzyl ester is dissolved in 50 mL of ethanol, to which is added 500 mg of 10% Pd-C, and the mixture is hydrogenated at 50 psi for 3 h. The resulting mixture is filtered and the solvent removed with a rotoevaporator to afford N-(2-ethoxycarbonyl-3-phenylpropyl)-L-valine.

Workup

  1. filtrationThe resulting mixture is filtered
  2. customthe solvent removed with a rotoevaporator

Sources & evidence

ORD record
ord-3ebb907a339047cbbfe4f006063c7f82
Source dataset
uspto-grants-1996_04
Patent number
US05504070

Reaction notes

Loading…