Ethyl cyanoacetate → HCID 15293924, compound

HRID 1720251Notes

Reaction equation

HRID 1720251 reaction equation
[C:1]1([S:7][C:8](=[N:12][NH:13][C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)[C:9](=O)[CH3:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(O[C:25](=[O:29])[CH2:26][C:27]#[N:28])C.C([O-])(=O)C.[NH4+]>CCO>[C:1]1([S:7][C:8]2[C:9]([CH3:10])=[C:26]([C:27]#[N:28])[C:25](=[O:29])[N:13]([C:14]3[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=3)[N:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 3

HCID 7764Ethyl cyanoacetateHCID 517165Ammonium AcetateHCID 53927081HCID 53927081, compound

Product 1

HCID 15293924HCID 15293924, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The reaction of 429 mg of 1-[(phenyl)thio]-1-[(4-methoxyphenyl)hydrazono]-2-propanone, 375 ul of ethylcyanoacetate and 178 mg of ammonium acetate as in Example 55, yielded 165 mg of 6-[(phenyl)thio]- 2,3-dihydro-2-(4-methoxyphenyl)-5-methyl-3-oxo-4-pyridazinecarbonitrile, mp 179°-180° C. (EtOH).

Sources & evidence

ORD record
ord-cd180c4cb9b043a89613feaa56a93492
Source dataset
uspto-grants-1996_04
Patent number
US05506228

Reaction notes

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