Benzocaine → HCID 178468670, compound

HRID 1720285Notes

Reaction equation

HRID 1720285 reaction equation
CC1(C)O[C:6](=O)[CH2:5][C:4](=O)[O:3]1.[NH2:11][C:12]1[CH:22]=[CH:21][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][CH:13]=1>>[OH:3][C:4]1[C:13]2[C:12](=[CH:22][CH:21]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:14]=2)[N:11]=[CH:6][CH:5]=1

Participants

3

Reactant 2

HCID 2337BenzocaineHCID 162492,2-Dimethyl-1,3-dioxane-4,6-dione

Product 1

HCID 178468670HCID 178468670, compound

Procedure

In a manner similar to that described in Example 58, Part A., 10 g (69 mmol) of 2,2-dimethyl-1,3-dioxan-4,6-dione and 11.4 g (69 mmol) of ethyl 4-aminobenzoate were tranformed into the title product: yield 10.86 g (72%); m.p. 233°-234° C.

Sources & evidence

ORD record
ord-56d0000a56394355be67e032080fa2ce
Source dataset
uspto-grants-1996_04
Patent number
US05506235

Reaction notes

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