Hydrogen Bromide → HCID 178428167, compound

HRID 1720291Notes

Reaction equation

HRID 1720291 reaction equation
C[O:2][C:3]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:26]3[NH:30][N:29]=[N:28][N:27]=3)=[CH:16][CH:15]=2)[C:6]2=[N:7][CH:8]=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1.Br>O>[CH3:11][C:10]1[CH:9]=[CH:8][N:7]=[C:6]2[N:12]([CH2:13][C:14]3[CH:15]=[CH:16][C:17]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=4[C:26]4[NH:27][N:28]=[N:29][N:30]=4)=[CH:18][CH:19]=3)[C:3](=[O:2])[NH:4][C:5]=12

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 178493972HCID 178493972, compound

Product 1

HCID 178428167HCID 178428167, compoundYield 79.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 90 mg (0.23 mmol) of 2-methoxy-7-methyl-3[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]-3H-imidazo[4.5-b]pyridine and 1 ml of 48% HBr was stirred at a room temperature for 1.5 hours. The product mixture was mixed with water to produce crystals, which was taken out and washed with water to obtain 70 mg of the intended compound.

Workup

  1. customto produce crystals, which
  2. washwashed with water

Sources & evidence

ORD record
ord-8d1ffcfe9c1e4361903e94ee57529047
Source dataset
uspto-grants-1996_04
Patent number
US05506238

Reaction notes

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