Ethanol → HCID 22923687, compound

HRID 1720301Notes

Reaction equation

HRID 1720301 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]2.[S:18]([O-:21])([O-:20])=[O:19].[Na+].[Na+].C(O)C>O>[OH:21][S:18]([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[NH:13][C:12](=[O:17])[CH:11]=[CH:10]2)(=[O:20])=[O:19]

Participants

5

Reactant 3

HCID 702EthanolHCID 24437Sodium SulfiteHCID 22923693HCID 22923693, compound

Product 1

HCID 22923687HCID 22923687, compoundYield 75.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 53.3 g of 6-(4-chlorobutoxy)carbostyril and 32 g of sodium sulfite dissolved in 500 ml of water and 200 ml of ethanol was refluxed for 1 day. The solution was allowed to cool and stand for 3 days and then filtered. The filtrate was made acidic with diluted hydrochloric acid. The solvent was removed by distillation. To the resulting residue was-added water, and the precipitate was collected by filtration to obtain 47.5 g of 6-(4-hydroxysulfonylbutoxy)carbostyril as a white powder.

Workup

  1. temperatureto cool
  2. filtrationfiltered
  3. customThe solvent was removed by distillation
  4. additionTo the resulting residue was-added water
  5. filtrationthe precipitate was collected by filtration

Sources & evidence

ORD record
ord-652e4fad5bd144df950bd61c501c82ec
Source dataset
uspto-grants-1996_04
Patent number
US05506239

Reaction notes

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