Chlorotrimethylsilane → HCID 22417726, compound

HRID 1720317Notes

Reaction equation

HRID 1720317 reaction equation
C([O:4][C:5]([C:7]1[N:8]=[CH:9][C:10]2[NH:11][C:12]3[C:17]([C:18]=2[C:19]=1[CH2:20][O:21][CH3:22])=[CH:16][C:15]([CH2:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[CH:14][CH:13]=3)=O)(C)C.C(N(CC)CC)C.Cl[Si](C)(C)C>C1(C)C=CC=CC=1>[CH2:23]([C:15]1[CH:16]=[C:17]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH:9]=[N:8][C:7]([CH:5]=[O:4])=[C:19]([CH2:20][O:21][CH3:22])[C:18]2=1)[CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 6397ChlorotrimethylsilaneHCID 8471TriethylamineHCID 53925498HCID 53925498, compound

Product 1

HCID 22417726HCID 22417726, compoundYield 70.1%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
-78 °C

Procedure

1.2 g of 6-phenethyl-4-methoxymethyl-β-carboline-3-carboxylic acid isopropyl ester is mixed in 25 ml of dry toluene with 2.5 ml of triethylamine and 0.78 ml of chlorotrimethylsilane and heated for 1 hour to 50° C. solution temperature. After concentration by evaporation to about half it is cooled to -78° C. and 5 ml of a 1.2 molar diisobutylaluminium hydride solution is instilled. It is stirred for 30 minutes at -78° C., mixed with 1.2 ml of ethanol and allowed to come to room temperature. 10.2 ml of 0.5-N NaOH and 10.2 ml of ethanol are added to the batch and stirred for 2.5 hours at room temperature. The batch is added to 35 ml of glacial acetic acid and extracted three times from ethyl acetate. The organic phase is washed in succession with dilute ammonia and saturated common salt solution, dried, filtered and concentrated by evaporation. The residue is chromatographed on silica gel with methylene chloride:ethanol=1:1 and 720 mg of 6-phenethyl-4-methoxymethyl-β-carboline-3-carbaldehyde is obtained, that in 8 ml of dimethylformamide is mixed in succession with 322 mg of hydroxylaminehydrochloride, 1.6 ml of ethanol, 322 mg of powdered potassium hydroxide and refluxed for 3 hours. Suctioning off yields 740 mg of 6-phenylethyl-4-methoxymethyl-β-carboline-3-carbaldehyde aldoxime of a melting point of 197°-198° C. This oxime is dissolved in 26 ml of dimethylformamide and mixed with a solution of 381 mg of N-bromosuccinimide in 3.4 ml of dimethylformamide and stirred for 15 minutes at room temperature. 1.38 ml of triethylamine and 0.26 ml of methylpropargly ether is added to the batch and stirred for 7 hours at room temperature. After concentration by evaporation it is spread in ethyl acetate/water and the organic phase is dried, filtered and concentrated by evaporation. The residue is chromatographed on silica gel with toluene:ethanol=9:1. After combining and concentrating by evaporation the corresponding fractions and recrystallization 251 mg (30% of theory) of 6-phenethyl-4-methoxymethyl-3-(5-methoxymethyl-isoxazol-3-yl)-β-carboline, of a melting point of 133°-135° C. (ethyl acetate) is obtained.

Workup

  1. temperatureheated for 1 hour to 50° C. solution temperature
  2. concentrationAfter concentration
  3. customby evaporation to about half it
  4. additionmixed with 1.2 ml of ethanol
  5. customto come to room temperature
  6. addition10.2 ml of 0.5-N NaOH and 10.2 ml of ethanol are added to the batch
  7. stirringstirred for 2.5 hours at room temperature
  8. additionThe batch is added to 35 ml of glacial acetic acid
  9. extractionextracted three times from ethyl acetate
  10. washThe organic phase is washed in succession with dilute ammonia and saturated common salt solution
  11. customdried
  12. filtrationfiltered
  13. concentrationconcentrated by evaporation
  14. customThe residue is chromatographed on silica gel with methylene chloride

Sources & evidence

ORD record
ord-cd908fd8ae914ea1ac84260e2293b8bd
Source dataset
uspto-grants-1996_04
Patent number
US05506234

Reaction notes

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