5-(4-Chlorobenzyl)-4-methoxymethyl-beta-carboline-3-methanol → 5-(4-Chlorobenzyl)-4-methoxymethyl-beta-carboline-3-carbaldehyde

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Reaction Steps

1.3 g (0.00354 mol) of 5-(4-chlorobenzyl)-4-methoxymethyl-β-carboline-3-methanol is stirred for 192 hours under argon at room temperature with 1.74 g (0.02 mol) of manganese dioxide in 200 ml of dichloromethane. The manganese dioxide is suctioned off, the filtrate concentrated by evaporation and the residue recrystallized from ethanol. Thus 0.96 g (74% of theory) of 5-(4-chlorobenzyl)-4-methoxymethyl-β-carboline-3-carbaldehyde is obtained, melting point 248°-250° C.

Provenance & Evidence