反应详情

To a solution in THF (20(3 mL) of 2-thiopheneacetamide (4.04 g, 28.6 mmol), prepared as in step 1, was added P4S10 (12,7 g, 28.6 mmol), and the vigorously stirred reaction mixture was placed in a Bransonic 221 bath and sonicated with ultrasound for 30 min. The reaction mixture was filtered and the filtrate was concentrated in vacuo. The crude product was taken up in CH2Cl2 and decanted from the solid residue. Pure 2-thiophenethioacetamide (2.45 g, 54% yield) was obtained by chromatography on silica gel (CH2Cl2).

1. customthe vigorously stirred reaction mixture
2. customsonicated with ultrasound for 30 min
3. filtrationThe reaction mixture was filtered
4. concentrationthe filtrate was concentrated in vacuo
5. customdecanted from the solid residue