反应详情

温度

-25 °C

To L-proline benzyl ester hydrochloride (0.98 g) in dichloromethane (20 ml) were added N-methylmorpholine (0.49 ml), N-(3-phenylpropionyl)-L-proline (1.00 g) and HOBt (0.60 g) under ice-cooling. After cooling to -25° C. , DCC (0.92 g) was added, and the mixture was stirred at a temperature between -25° C. and 0° C. for 2 hours, and then at room temperature for 14 hours. The reaction mixture was treated and purified as in Example 7-A) to give 1.39 g of the title compound.

1. temperaturecooling
2. waitat room temperature for 14 hours
3. additionThe reaction mixture was treated
4. custompurified as in Example 7-A)